Sentence examples for front-line therapy from inspiring English sources

For many cancers, DNA-damaging agents are front-line therapy.

A major challenge will be how to design clinical trials to move these agents into front-line therapy.

"The previously unrecognized variety of PfCRT mutations, and the rapid rise of variants beneficial for the parasite against this particular front-line therapy, is definitely worrying," she says.

A total of 12 (43%) patients had refractory disease with evidence of progression within 3 months following completion of front-line therapy.

Lack of effective treatment for patients who progressed on or recurred after front-line therapy allowed trials to avoid obfuscation of OS by post-progression therapy.

In the first validation set, patients receiving front-line therapy achieving EMR or MMR had superior outcomes at 24 months (EMR: EFS, 83% v 50%; P =.0015; MMR: EFS, 82% v 46%; P <.001).

Consolidative Bv post HCT was given to 18 (64%) mainly due to relapsed disease within 12 months following front-line therapy with a median (range) of 15 (6–16) doses administered pre- and post-HCT.

Paclitaxel in this dose and schedule should not be used as front-line therapy for patients with ES-SCLC.

Reasons for failure of front-line therapy included progressive disease (PD; n = 33) and persistent disease with concurrent allograft rejection (n = 3).

Further studies are planned to determine whether the addition of nelarabine to front-line therapy for T-cell leukemia in children will improve survival.

PURPOSE: To evaluate the efficacy of a low-dose chemotherapy regimen in children with Epstein-Barr virus (EBV) -positive, post-transplantation lymphoproliferative disease (PTLD) after organ transplantation who have experienced failure with front-line therapy for PTLD.