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The generation of tissue resident memory (TRM) cells at the body surfaces to provide a front line defence against invading pathogens represents an important goal in vaccine development for a wide variety of pathogens.
There also needs to be some improvements in front line defence.
The German defensive strategy was to operate a front line defence of sufficient strength to defend against an initial assault and move operational reserves forward before the enemy could consolidate their gains or overrun remaining German positions.
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The whole of the Ottoman Eighth Army's right flank forces holding the front line defences had rapidly collapsed.
The 180th Brigade had captured the front line defences and about 600 prisoners, while advancing 6000 7000 yards north of their starting point, suffering 414 casualties.
By 07:20 on 19 September the 180th Brigade had captured the front line defences and about 600 prisoners, one company establishing a bridgehead across the mouth of the Nahr el Faliq 5 mile behind the Ottoman front line.
These casualties were inflicted despite Russell's attempts to keep the number of soldiers in the front line defences to a minimum and to rely on artillery and machine guns as his primary means for defending against counterattacks.
During the attack on Tulkarm, the infantry created a gap in the Ottoman front line defences, through which cavalry from General Edmund Allenby's Egyptian Expeditionary Force (EEF) rode north.
During the course of this attack, the infantry created a gap in the Ottoman front line defences through which the Desert Mounted Corps rode northwards to begin the cavalry phase of the battle.
The battle began with the detonation of 19 mines, which devastated the German front line defences, followed by a creeping barrage 700 yards deep, covering the British troops as they secured the ridge, with support from tanks, cavalry patrols and aircraft.
One of the host's front line defences against infection is to produce an oxidative burst, in which various reactive oxygen species (ROS) are released to create an unfavorable environment for the bacteria.
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