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Our analysis links the transient phenomenon of front initiation to the bifurcations of reaction diffusion systems with active boundaries.
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The annual Platinum Card charges $550 in annual fees; the invitation-only Centurion Card charges members $2,500 a year, plus an up-front initiation fee.
In the context of our promoter studies we changed the ATG-flanking sequence by introducing five additional nucleotides in front of the initiation codon.
The influence of the one-dimensional intrinsic instability of the detonation front upon the direct initiation has also been examined via direct numerical simulations.
With the aim of changing the sequence precisely in front of the translation initiation codon ATG, in accordance to Kozak [ 33] and Luetcke et al. [ 34], the five nucleotides CTCAA were inserted between the restriction sites XhoI and NcoI (NcoI including the translation initiation codon) of pluc to give pluc-enh (Fig. 1A).
In patients with metastatic disease, progression-free survival (PFS) was defined from the initiation of front-line treatment until disease relapse or death.
As clinical relapses are believed to be originated from these chemotherapy- and hormone-resistant CK-19mRNA-positive CTCs (Xenidis et al, 2007), we sought to determine the clinical relevance of the detection of these cells in patients with newly diagnosed MBC, before the initiation of front-line chemotherapy, using the same RT-PCR assay.
Before the initiation of front-line treatment, patients had complete clinical, biochemical and imaging staging (including computed tomography scans of chest and abdomen, as well as a whole-body bone scan) and serum levels of tumour markers (CEA and/or CA 15.3).
And the pressure is on her already as she has to do an initiation performance in front of the rest of the team.
A Kozak consensus GCCACC is inserted in front of the IGFBP5 translation initiation site to increase the translation efficiency.
Peripheral blood or bone marrow aspirates are obtained from patients who sign an informed consent, before the initiation of adjuvant or front-line treatment as part of their initial evaluation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com