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They also by necessity considered a single frequency of screening (from annual to triennial), from which extrapolation to other frequencies is challenging.
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The first step in developing toxicity values is identifying, for each data set, a point-of-departure (POD) dose, from which extrapolations to environmentally relevant doses are made.
Although this approach does not a priori account for cell subset differences, the gene expression data generated may provide important information from which extrapolations regarding relative distributions and phenotypic differences can be made.
Other challenges would be non-linear model of which extrapolation from accelerated condition to label storage condition becomes risky.
However, the degree to which extrapolation factors derived for one agent, and only from sperm counts, can be generalized is not known.
In addition, there are caveats about populations to which extrapolations from our findings may be made.
That doesn't make them less impressive — just not necessarily deeds from which one can construct grand extrapolations.
Calibration curve was drawn by running suitable concentrations of standard solutions, from which the concentrations of the elements were obtained by extrapolation.
The extrapolation allows the full work of fracture to be determined, from which the fracture energy may be obtained.
And the title, striking against the experience, creates sparks of metaphorical extrapolation: The Jews of Europe lived carefree, as in a park, until they wandered into frightening canyons of shadows from which the escape routes were narrow and distant.
Mechanism-based models can facilitate this process of translation/extrapolation beyond the experimental conditions from which the data have been collected.
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