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Expression of CENP-A appeared to increase with the grades of differentiation of HCC cells from well differentiated to poorly differentiated (Figure 2B D).
Presumably, these areas of intratumour diversity compete for dominance, and eventually the most aggressive prevail, which is a general mechanism by which poorly differentiated (ER-negative) may gradually evolve from well differentiated (ER-positive) tumours.
Brown and his colleagues "clearly demonstrate that the most parsimonious and coherent interpretation for the data is that there were at least three independent domestications of [rice] from well differentiated ancestral populations in Asia," she says.
Microscopically, tumors range from well differentiated to highly anaplastic.
The histological grade of tumors can range from well differentiated to undifferentiated types.
All immunizations were carried out using whole cells and membrane preparations from well differentiated human TCCs.
Similar(40)
Colitis cystica profunda (CCP) is a nonneoplastic condition characterized by misplaced glands deep to the muscularis mucosae of the colon and may be difficult to differentiate from well-differentiated mucinous adenocarcinoma.
Neuroendocrine tumours may manifest at different degrees of differentiation, from well-differentiated (carcinoids) to poorly differentiated, or anaplastic or somatic/neuroendocrine mixed forms.
The potential pitfall of using this contrast agent in clinical image interpretation is difficulty in reliably differentiating small cysts, hemangiomas, and metastases from well-differentiated HCCs, as these lesions do not have Kupffer cells, do not consume ferumoxides and remain high in signal intensity on T2 * sequences [ 13].
A 60-year-old man suffered from well-differentiated thyroid carcinoma and underwent total thyroidectomy.
Such lipomas cannot be distinguished from well-differentiated liposarcoma with imaging alone, and biopsy is mandatory to exclude well-differentiated liposarcoma and the possibility of dedifferentiation [17].
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