Exact(11)
NADH is mainly produced from two pathways, the glycolysis and the electron transport shuttle system.
Perhaps the basis lies in the fact that resistance can result from two pathways, either sterically with large residue substitutions, or dynamically by disrupting the H-bonding network in the active site.
An enrichment analysis of such pathway crosstalk requires evaluating the enrichment of interactive genes from two pathways correspondingly.
Then by two-way RWR, we can find the interactive genes from two pathways, and select any pathway-pair as a crosstalk significantly (Additional file 8: Table S8).
As cancers in the present study were derived from a cohort receiving colonoscopy, they were composed of cancers from two pathways.
The ingestion route receives exposures from two pathways: dietary ingestion and nondietary ingestion (caused by hand-to-mouth or object-to-mouth activities).
Similar(49)
To the best of our knowledge, the formation of COx mainly originated from three pathways which was consist of direct pyrolysis of methanol, transformation reaction of methanol with steam, and methanation reaction of methanol.
p-values were not available from six pathways due to presence of only one TF (see Additional File 3).
We analyzed 96 cancer-related genes from four pathways including stem cell transcription factors, homeobox genes, wnt signaling, and epithelial to mesenchymal transition (EMT).
We further identified six networks of co-expressed genes that included prominent genes from three pathways: protein synthesis (particularly mitochondrial ribosomal genes), oxidative phosphorylation, and autophagy, with expression patterns suggesting these pathways decline with age.
The sub-network after filtering is shown in Figure 2, which has 95 nodes with 186 interactions derived from six pathways and is organized to show the underlying relevant pathways based on data from MSigDB.
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