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There was no significant change in either brachial systolic or diastolic BP from trimester to trimester, but brachial pulse pressure was significantly lower in the third trimester compared with the second (P = 0.004).
In the low-BMI group, arginine flux decreased from trimester 1 to 2, but NO production did not change.
When expressed per whole body, this reduction in arginine flux in the low-BMI group from trimester 1 to 2 did not achieve statistical significance.
Systolic blood pressure (SBP) was not different between the low-BMI and normal-BMI groups in either trimester, and it did not change significantly from trimester 1 to 2 (Table 2).
"Blind periods" produce further problems: Toxoplasma infections are dangerous during any time in pregnancy, but the risks of transmission to the foetus and the resulting clinical affections differ from trimester to trimester [ 26].
Not surprisingly, plasma NOx concentration was also higher in the women with low BMI at the end of trimester 2. A closer examination of the data reveals that NO synthesis and concentration trended lower from trimester 1 to 2 in the women with normal BMI.
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Women were excluded from trimester-specific analyses when trimester-specific data were missing, but were included in all other analyses with available exposure data.
Gestation-dependent changes in killer-cell immunoglobulin-like (KIR) receptor repertoire have been reported in uNK cells isolated from first trimester decidua from 6 to 12 weeks of gestation (Sharkey et al., 2008; Marlin et al., 2012).
Fetal tissues were obtained from first trimester products of conception from a normal white European cohort.
Gestational age was calculated from the first day of the last menstrual period, or from first trimester ultrasonography.
Post hoc analyses of data from 228 women from a prospective, randomised, multicenter study comparing metformin to placebo from first trimester to delivery.
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