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All studies were performed in the US, one study additionally included patients from Canada [ 39].

We analyzed a subset of patients from a prospective cohort study performed in the ED.

The study was performed in the time from January 2009 until November 2009.

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The study was performed in the medical surgical ICU during the period from April 2015 through November 2015.

This was an observational study performed in the ED UKMMC from 7 August 2007 till 28 August 2008.

A prospective, observational cohort study was performed in the ICU at Hôpital Pontchaillou from September 15, 2010 to March 15 , 2011

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Four experiments were performed in this study.

HJM performed in vitro study.

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