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The population derived from this mutation process will have a satisfactory factors τCPU = 0.81 and τB = 1.
The skeletal dissimilarities of the Lrp5 G171V mutant to the other mutants suggest that other, non-sclerostin-associated mechanisms might account for the changes in bone mass resulting from this mutation.
Moreover, aside from this mutation, there is also a very high correlation between the susceptibilities of the two drugs.
Furthermore, it has been shown that a N51S mutation in the DNA binding homeodomain abolishes the DNA binding ability of several Hox genes [22] and, indeed, the AML-associated fusion gene NUP98-HOXD13 (ND13) fusion also loses its leukemic effect from this mutation [19].
Genetic selection by pig breeders away from this mutation has not fully resolved the PSE problem.
Using this yeast model, the authors perform a comprehensive search for genes that, when inactivated, suppress or exacerbate the phenotype resulting from this mutation.
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Although carrier sires of the BMP15 mutation are systematically discarded from breeding, this mutation is still present in the female population and might contribute to this interaction.
We have implemented gene-editing strategies for COL7A1 frame restoration by NHEJ-induced indels in epidermal stem cells from patients carrying this mutation.
The role of residue Arg113 is somewhat problematic to evaluate from ELISA, because this mutation affected the reactivity of the anti-IL-11 antibodies.
Clinic and pathological characteristics of tumors from individuals carrying this mutation are shown in Table 5.
In a similar study from Gambia[ 12], this mutation was found in 36% of HCC patients sera, in 15% cirrhotic patients and in 6% of the control group.
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