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Most of the remaining samples differed from this founder BC type by one or two additional point mutations within the target regions described here.
From this founder mouse, we established a new line of GAA-repeat-expansion-containing FXN YAC transgenic mice on a predominantly C57BL6/J background, designated YG8sR.
The B10.M-DR4 mice were maintained as heterozygotes for the DR4 transgene, because homozygous B10.M-DR4 mice from this founder do not survive.
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I wasn't expecting a term sheet from this meeting, but this founder had received great press and a healthy amount of seed funding for her rather brilliant family finance startup; I wanted her to get a sense of what it would take to close a Series A or even B round, and this investor is known for candor with founders.
This founder cell contained an advantageous mutation leading to a clonal expansion of a large population of cells descended from the founder.
This prescription, from the founder of that quintessential 1960s publication the Whole Earth Catalog, comes as a surprise.
Director Kate Mueth, sensitive to the satire of this piece from the founder of the Theater of the Ridiculous, stays close to Ludlum's original staging from his small theater at One Sheridan Square, now in a barn with a fine set by Brian Leaver and lighting by Sebastian Paczynski.
Two actors, Tom Aulino and David Greenspan, play a total of eight characters constantly and thrillingly making speedy costume changes, the faster the better to retain the hilarity of this piece from the founder of the Theater of the Ridiculous; the production under Kenneth Elliot's fine direction stays close to Charles Ludlam's original staging from his small theater at One Sheridan Square.
You won't get this answer directly from the founder, so ask to talk to other key team members to make sure everyone is carrying their weight, and communicates effectively.
Stronger selection results in greater evolution towards the fittest sequence and, in this case, away from the founder sequence.
This is a mouthful coming from the founder.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com