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Only when leaves are damaged is indican released from this compartment.
Biochemistry 39, 7662 7677 (2000).A great study that demonstrates the requirement of processes extrinsic to the lysosomal membrane for efficient cholesterol exit from this compartment.
To understand how cholesterol accumulation influences late endosome function, we investigated the effect of elevated cholesterol on Rab9-dependent export of mannose 6-phosphate receptors from this compartment.
A member of a second family of transporters (RND), which depend on a proton motive force gradient for their function, was recently shown to reside in late endosomes where it facilitates lipid exit from this compartment.
By combining the cell cycle length predicted by the model with measurements of total cell population and mitotic rate, this approach facilitates the quantification of exit from this compartment without the need for a direct marker of that event.
Thus, we hypothesize that, in part, NPC2 rapidly traffics cholesterol between closely appositioned membranes within the multilamellar interior of late endosomal/lysosomal proteins, ultimately effecting cholesterol egress from this compartment.
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To explore whether TGFβ1 influences miR-26a and miR-30c expression in extracellular vesicles, we isolated this compartment from NRK-52E cell supernatants.
As we lack further unambiguous markers to clearly distinguish the mitochondrial compartment, we therefore prefer to not consider the contribution of this compartment from our NAF gradients.
In transfected cells exit of ClC-6 from this early compartment seems to be the rate-limiting step, whereas endogenous ClC-6 leaves the early endosomal compartment and is sorted to late endosomes.
Transport from this vesicular compartment required the presence of an active proton pump; when blocked with the specific inhibitor bafilomycin A1, entry into the cytoplasm was blocked [ 31].
UPR takes place in the ER lumen and is a major signal transduction pathway aiming to alleviate ER stress by removing accumulated unfolded proteins from this cellular compartment [ 18].
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