The dose was escalated from a starting dose of 50 mg until the MTD was determined.
In fact 78.3% of our patients could benefit from a starting dose below 15 mg prednisone.
Cyclophosphamide dose was fixed at 500 mg m−2 and losoxantrone dose was escalated from a starting dose of 30 mg m−2 through 40, 45 and 50 mg m−2.
There were 13 escalations of dosage, from a starting dose of 192 mg m-2 to 10 g m-2.
If the adverse event resolved, reinstitution of treatment occurred at a dose reduced by 200 mg per d from the starting dose.
Patients initiating liraglutide treatment should be transferred from the starting dose of 0.6 to 1.2 mg/day after at least 1 week [ 12].
Stepwise reductions in axitinib dose from a starting dose of 5-mg bid to a minimum of 2-mg bid were mandated by the occurrence of treatment-related toxicities of grade ≥3 severity.
13 18 The dose was titrated by 0.6 mg every 7 days from a starting dose of 0.6 mg once daily until the maximum dose of 1.8 mg once daily was achieved.
From a starting dose of 12 mg m−2, the dose of AMD473 was doubled until grade 2 drug-related haematological toxicity was observed in one out of three patients treated at 96 mg m−2.
For minimization of gastrointestinal side effects, patients naive to metformin will be titrated over a maximum of 8 weeks from a starting dose of 500 mg once daily to a maximum dose of 1,000 mg b.i.d.
