From the first cycle onwards both processes result – as evidenced by SEM – in progressive crack formation, dissociation of the active material from Li6PS5Br and carbon and consequential capacity fading.
Furthermore, retrospective analysis of the O'Shaughnessy et al (2002) study showed no reduction in efficacy when doses of capecitabine and docetaxel were reduced because of adverse events from the second cycle onwards (Professor C Twelves, personal communication).
Other important toxicities were long-lasting lymphocytopaenia, observed from the first cycle onwards and present in every patient irrespective of the given dose, and some nonhaematologic toxicity, that is, fatigue, loss of appetite, nausea and vomiting.
Antiemetic prophylaxis (metoclopramide or domperidone) could be given from the first cycle onwards, and loperamide to prevent diarrhoea in subsequent cycles following grade 2/3 diarrhoea; patients with nausea or diarrhoea despite these measures could be treated with granisetron or odansetron, but additional treatment with corticosteroids was not allowed.
As sorafenib was co-administered only from day 4 of the first cycle onwards, the effect of sorafenib on adduct formation can be excluded in our study.
Sorafenib was given twice a day from the fourth day of the first cycle onwards, that is sorafenib had not been co-administered when blood samples were collected for this study.
At lower temperature-strain amplitude combination, the locking type B serrations appear from first cycle onwards that is persistent during the entire fatigue life.
In the range 2.5 4.5 V, the third cycle capacities are 175 ± 5 mAh g−1 for the bare and 3% NiO-coated compounds, but capacity-fading starts from fifth cycle onwards.
