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Overall, however, the results from the PDD analysis did not differ greatly from the RDD analysis.
Overall, the risks calculated from the PDD analysis differed only slightly from the RDD analysis, if at all.
In general, odds ratios from the PDD analysis were slightly higher than the RDD analysis for exposure levels above the 50th and 75th percentiles at shorter latency periods (see Additional file 2: Table 4).
Overall, the results from the PDD analysis did not differ greatly from the RDD analysis and any differences were well within the variation present in the RDD data, which formed the "input" to the PDD analysis.
Although our results from the PDD analysis did not differ greatly from the RDD analysis, it remains important to assess exposure as accurately as practical in an epidemiological investigation.
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Representative electrolyte solution is derived from the PDDs determined with Molecular Dynamics in section 2.1.
Even for common drug classes such as antihypertensive drugs, it is not possible to calculate the PDD simply from the number of prescribed DDD without the information of the number of patients treated and the time of medication.
While a single prescription does not contain a dosage recommendation and is not suitable for the calculation of PDD, the large data set in combination with a pseudonymised patient follow-up enabled us to calculate the PDD solely from prescription data.
This approach, i.e. to calculate the PDD solely from the prescription data, is appropriate since we included only continuous prescriptions and we checked that every patient also received the analysed drug class, both before the study period—as a sort of run-in period to identify prevalent users and also after the 3-month period under study.
Numerical results of the global sensitivity indices computed for smooth systems reveal significantly higher convergence rates of the PDD approximation than those from existing methods, including polynomial chaos expansion, random balance design, state-dependent parameter, improved Sobol's method, and sampling-based methods.
In treatment, the PDD clinic appropriates strategies from the field of Alzheimer's disease, capitalizing on drugs that enhance ACh signaling, i.e. AChE inhibitors.
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