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This is partly due to the fact that from the initially planned ten study centers two did not participate in the study because of organizational reasons.
1) The recruitment rate was slower than expected and the recruitment period had to be prolonged from the initially planned three months to six months.
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The interim analysis included 114 randomised patients (approximately two-thirds of the initially planned sample size) from the target population who should have completed the treatment period (week 12) at the date of analysis as well as all patients having completed week 24 at the cut-off date.
Due to time and budget constraints, many of the initially planned cutscenes and stories were cut from the final product.
An interim analysis was prospectively planned to confirm or reassess the initially planned sample size.
While such initiatives have benefits on their own, the data they generate can be reused for a variety of purposes that differ from that initially planned, which constitutes the real potential of open geospatial data, software and standards.
In addition to the cutbacks, Starbucks said it would open fewer than 200 new stores in the United States next fiscal year, down from the 250 initially planned.
Some tracks and demos from the album (initially planned for release in 2008) were leaked on the internet in 2006, and a documentary entitled The Return of Courtney Love, detailing the making of the album, aired on the British television network in the fall of that year.
The Greek government, which is seeking a three-year bailout worth up to €86bn (£60bn) to avert financial meltdown and a chaotic exit from the eurozone, had initially planned to go without fresh help from the IMF as it considers the agency too wedded to draconian austerity measures.
The complexity of such sequences meant the budget rose from an initially planned $70 million to around $100 million.
The reopening, initially planned for December, was twice delayed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com