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Translocation into the bloodstream and subsequent circulation of molecules from fungi, such as RNA, DNA or peptidoglycans, may initiate systemic immune responses and lead to disease remote from the initial site of fungal infection [ 37, 38].
When the tip height reaches 5.9 Å, as shown in Figure 2b, the atom is pulled up obviously from the initial site.
This interaction can occur distant from the initial site of xenoantigen, but monocytes remaide void of costimulatory signals until their interaction with T cells.
Detection of the virus principally among plasma samples of the animals supports the PCR data in showing the virus likely disseminates to multiple organ systems from the initial site of infection by hematogenous spread in the cell-free blood component.
For the remaining animals, the correlation of peak viral RNA in the blood and severe illness suggests a progressive infection that seeded multiple organs simultaneously from the initial site of virus replication.
Furthermore, addition of purified SpeB with either a wild-type or ΔspeB M1 strain into a mouse air sac model of infection led to accelerated and increased tissue necrosis, as well as dissemination of the organism away from the initial site of infection [47].
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The intracellular delivery of these enzymes and their interaction with eukaryotic cofactors is highly correlated with the dissemination of bacteria from the initial sites of infection and the induction of sepsis [5], [16] [18].
The ΔF11L virus is also attenuated in intranasal mouse models of infection, as it is impaired in its ability to spread from the initial sites of infection to the lungs and spleen.
Both cancers were mammographically occult and detected on MRI, remote from the initial sites of cancer, and thus favoured to represent second primary tumours.
This suggests that virus entry into the nervous system can occur by retrograde axonal transport either from neurons innervating the initial site of replication or from the olfactory epithelium after viraemic spread.
For all the networks, the two-mile move from the Pepsi Center, the initial site of the Democratic convention, to Invesco Field, where Mr. Obama will speak Thursday, may be more grueling than the subsequent move to St . Paul
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