OS was measured from the date of the first pemetrexed dose to the date of death due to any cause.
DMFS was calculated from the date of the first NPC diagnosis to the date of distant relapse or patient censoring at the date of the last follow-up.
Follow-up was from the date of the second screening until the date of death, date of leaving the United Kingdom, or December 31 , 2010
DMFS was determined from the date of the first NPC diagnosis to the date of distant relapse or patient censoring at the date of the last follow-up.
RFS was calculated from the date of randomization until the date of the first relapse or the date of death in first complete remission.
RFS was measured from the date of resection to the date of the first recurrence documented by imaging or pathologic confirmation or until the censoring date of May 31 , 2010
Patients' cohort entry dates were defined as the date of the first statin prescription after discharge from hospital.
The duration of response was calculated from the date of first documented response until the first date of disease progression.
We determined time at risk from the date of first observation until the date of death, emigration, first SAB, or 31 December 2009, whichever came first.
Patients were followed from the date of first receiving cis-platinum until the date of first evidence of progression, or the date of death, depending on the analysis.
