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Chains of reasoning from secondary causes are often essential to making big discoveries.
It was concluded that the presence of comorbidity, the patient's age, the existence of trigger and relaxing factors, the pain in other body parts that accompanies headache (neck, back and low back pain) and the quality of pain in terms of location and duration were all important clues for ER physicians in making an accurate differentiation between primary headaches and those from secondary causes.
Beginning with a childhood population and trying to match those developing ESRD produced essentially 50% with a clinical etiology related to early and progressive renal disease from secondary causes.
Approximately 25% of cases of MG are thought to result from secondary causes [ 6], most commonly systemic lupus erythematosus, infection (e.g. hepatitis B or C virus), malignancy, or drugs, whereas the remaining 75% of cases represent primary disease [ 6].
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Secondary causes, from the death certificates, were not available.
In the presence of hyperreninism, it is important to differentiate a primary source such as secretion by a renal tumor from a secondary cause such as renal arterial stenosis or renal parenchymal disease.
It is well established that hypothermia and alkalinization each separately protect neurons from ischemia and ischemia-induced secondary causes of neuron death, but there are no data on the neuroprotection provided by simultaneous hypothermia and alkalinization.
Cause of death was attributed in a hierarchical fashion from both the primary and secondary causes of death.
Children were excluded from the study when diagnosed with secondary causes of obesity (i.e. hypothyroidism, hypogonadism and pituitary disorders or genetic syndromes), diabetes and/or when they used glucose- or lipid- lowering medication, corticosteroids or drugs acting on the central nervous system.
Secondary causes were also identified from the verbal autopsies.
We were careful to delineate a population of patients that were beyond the acute phase of brain injury and were believed unlikely to deteriorate from secondary neurological causes.
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