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GSNAP used a peak of 86 MB on the exact match datasets, 101 MB on the mismatch datasets and 170 MB on the indel datasets, with memory usage varying from read to read.
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"It could be anxiety, or simply the normal variation from reading to reading that you might see just in the few minutes it takes to switch arms," Dr. Resnick said.
And that, more than anything, is why I'll be celebrating the publication of Going Somewhere -- my debut book about a cross-country bicycle trip and a search for direction -- by riding my bike from reading to reading: I want to be joyful, witty, clear.
The drawback of our technology is that the variation from reading to reading is significantly higher than that of HPLC.
Your pH meter should not only be accurate, but its results should also be consistent from reading to reading.
"The core problem of literacy in middle school is you're transitioning from learning to read, to reading to learn," said Josh Thomases, deputy chief academic officer for the Education Department.
And tutoring during the K-3 years helps ensure children can make the pivotal transition from "learning to read" to "reading to learn".
Harvard educational psychologist Jeanne Chall famously called this phenomenon the "fourth grade reading slump," where children cannot make the transition from learning to read to "reading to learn," which hinders their learning in all other subjects.
When offered in the context of an aligned, seamless continuum of early learning, expanding access to full-day kindergarten becomes a critical strategy for closing achievement gaps by third grade, the stage at which success in school depends upon a child's ability to transition from "learning to read" to "reading to learn".
By plotting the fraction of aligned reads against the number of differences maximally allowed in the alignment process (Fig. 1), we observed that the increase from perfectly matching reads to reads with up to four differences is not uniform.
Also here, MetaGeneAnnotator has the highest gene prediction harmonic mean (94%) as depicted in Figure 2. From error free reads to reads with 0.49% errors, a drop in harmonic mean of ~9% is observed for all gene prediction methods (except for Orphelia with 12%).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com