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Human diseases such as atherosclerosis and cancer might occur in part from oxidant damage to tissues.
The reason may include that mitochondria can generates ROS and mtDNA lacks histones to protect DNA from oxidant damage.
The data from CEBPG knockout mice support a role for CEBPG in protecting lungs from oxidant damage.
The structure of vitamin E, with its hydrophobic side chain, makes it unique and indispensable in protecting cell membranes from oxidant damage [ 8, 9].
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GSTT1 and GSTM1 are active in the elimination of several products resulting from reactive oxidant damage to DNA and lipids, such as organic epoxides, and hydroperoxides.
The period of time required for recovery from exercise-induced oxidant damage is unknown, but in humans, isoprostane production returned to baseline within 24 hours following exercise [ 11, 12].
Moreover, the enhanced cellular antioxidant capability and antioxidant function of redox-signaling in cancer cells result in an increase of cell resistance to oxidant, defend cancer cells themselves from oxidative damage, and favor their metastasis [ 14].
This was accompanied by significant declines in both oxidative stress and plasma markers of oxidant damage.
Photochemical Oxidant Damage -- 17.5.3.
Stein, T. P. & Leskiw, M. J. Oxidant damage during and after spaceflight.
Mambo, E. et al. Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations.
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