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While TLX is in the process of escaping from orphanhood, future ligand design needs to progress in parallel with improved understanding of (i) the binding cavity or surfaces to target with small molecules on the TLX ligand binding domain and (ii) the nature of the TLX coregulators in particular cell and disease contexts.
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A fundamental qualitative descriptive study was conducted to develop a culturally relevant and comprehensive description of the experiences of orphanhood from the perspectives of Ugandan youth.
The objective of the current article is to describe the experiences of entering into orphanhood from the perspectives of Ugandan youth orphaned by HIV/AIDS.
I see his point, but it's still a long way from Pippi's merry orphanhood to the emotional voiding and gothic glare of the woman in this film.
This, in its invocation of orphanhood, is subtly different from the way the products, and producers, of Bengali humanism saw themselves; yet the whole business of "seeing" was clearly as important to the latter as it has been to Naipaul, and for similar reasons: as something crucial to the creation of an oeuvre, a canon, a tradition.
Immediate effects of orphanhood investigated were trauma from living in a household with a death in the last three years or a sick adult member, stigma and discrimination (being treated worse than other children in the household), frequent residence changes (> 1 move) and residence in a poorer household (poorest quintile of households based on ownership of assets).
The analyses found significant differences between the orphanhood groups on perceived social support from the family but not from friends and significant others.
"The more you know about him, the more you see him reframing tragic moments of his own life and fixing them in his films," Mr. McClure said, pointing especially to "The Kid" (1921), in which a child's brutal separation from his parents mirrors Chaplin's own effective orphanhood.
Data from South Africa have indicated that the association between orphanhood and poor psychological health is mediated through poverty and stigma associated with AIDS orphans (Cluver, Gardner, & Operario, 2008, 2009).
We use quantitative and qualitative data from Eastern Zimbabwe to measure the effects of orphanhood on psychological distress and to test mechanisms for greater distress amongst orphans suggested in a recently published theoretical framework.
This suggests that more work is needed to investigate the effects of orphanhood on male adolescents using data from a variety of contexts, especially since the majority of existing studies have focused on young women.
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CEO of Professional Science Editing for Scientists @ prosciediting.com