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The variety of tropoelastin isoforms results from multiple alternative splicing of the primary transcript.
When first-line therapy fails, the treating physician needs to select a new regimen from multiple alternative possible drug combinations.
Moreover, higher eukaryotic genes may frequently be regulated from multiple alternative promoters.
Although X-ray crystallography reveals atomic coordinates with relatively high accuracy and precision, the resulting electron density maps contain contributions from multiple alternative conformations reflecting the ensemble average of 10 10 copies of the protein in one crystal (Rejto and Freer, 1996; Smith et al., 1986; Woldeyes et al., 2014).
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In the conceptual design stage of new product development, one of the major challenges is how to effectively determine the single best scheme from multiple alternatives.
In their previous works, the authors offered a new method for multiple attribute decision synthesis, SyMAD-3, which helps to choose an effective construction project alternative from multiple alternatives by assessing various construction, technological and occupational safety solutions, based on a set of quantitative attributes.
Computationally efficient match measures defined so as to benefit from the availability of multiple alternative human segmentations, are also proposed.
In addition to unique probe sets, the Affymetrix GeneChip® consists of non-unique probe sets that recognize multiple alternative transcripts from the same gene (probe set type, "_a"), and probe sets with common probes among multiple transcripts from separate genes ("_s" suffix) (Affymetrix, 'Array Design and Performance of the GeneChip® Rat Expression Set 230').
For example, a decreased expression of Trp53 in microarray analysis was measured only in two probe sets that recognise multiple alternative transcripts from the same gene each, whereas a third definite probe set did not recognise any modulation of expression.
Affiliated Managers Group continued to execute on its long and successful acquisition strategy by announcing new deals to add minority positions in six firms, including a five-for-one transaction in which it acquired minority positions in multiple alternative investment firms from a Goldman Sachs-affiliated private equity fund.
Note that the creation of annotations.gff' goes beyond simple interval intersection, as gene structures are normalized from multiple possible alternative transcripts to a single transcript that is chosen by the user depending on what is most relevant for the analysis.
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