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CS chains have been proposed to function in two distinct ways: they can interact with a ligand either to present it to its receptor (positive function) or to sequester it from its receptor (negative function) [64].
The bacterial toxin PTX promotes ADP-ribosylation of a cysteine residue on the G protein α-subunit, uncoupling it from its receptor and preventing its activation (49).
In this manner, a cargo is unlikely to return through the NPC once it has dissociated from its receptor in its destined compartment.
For HRV-A2, the mildly acidic pH in these compartments leads to dissociation of the virus from its receptor.
Therefore, we sought to determine the relationship between the lysine-dependent conformation of plasminogen and its dissociation rate from its receptor.
Collagen is a major agonist for platelets, operating through an immunoreceptor-like signalling pathway from its receptor GPVI.
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Short SDF1α-peptides derived from its receptor-activating domain are capable of activating the SDF1α specific receptor CXCR4.
The mechanisms of TRAIL resistance are not fully understood, but may occur at multiple levels from its receptors to executor caspases within its signaling pathway [2], [4].
This section explores system sensitivity to the effective (microenvironment-dependent) dissociation constants of VEGF from its receptors over the wide ranges reported in literature.
The role of AChE is to remove acetylcholine (ACh), the cholinergic signal molecule, from its receptors (AChRs) in the plasma membrane of the target cells.
In resolution of this interesting conundrum, we found that while in the old muscle this protein is localized intracellularly within the myofibers (away from its receptors and from satellite cells), in the young muscle, FGF-2 is located mostly extracellularly in the basement membrane, which is the niche of muscle stem cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com