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Most cancer cells are thought to originate from genome damage.
Plant organelles (both mitochondria and chloroplasts) have a third line of defense in addition to biochemical protection from genome damage and post-damage repair of DNA lesions.
Among the isoenzymes, the pi-class GST (GSTπ) encoded by the GSTP1 gene is implicated in a large variety of detoxification and metabolism reactions, which prevent cells from genome damage and cancer initiation [ 9, 10].
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1BR3 normal and 1BR3 SV40 1BR3LT were a gift from Prof. Alan Lehmann (Sussex Centre for Genome Damage and Stability, University of Sussex, UK) and maintained in DMEM containing 15% foetal bovine serum 40 U/ml Penicillin and 40 μg/ml Streptomycin.
Biological doses from indirect genome damage are calculated for each parameterized flare spectrum by integration over the X-ray opacity of water.
Therefore, NPBs give direct evidence of genome damage resulting from misrepaired DNA breaks, which cannot be detected when MNs are scored as the only end point.
Genome damage and defective repair are etiologically linked to neurodegeneration.
Conserved DNA-damage responses (DDRs) sense genome damage and prevent mitosis of broken chromosomes.
The broad research focus of my lab is genome damage induced by oxidative stress and its implication in carcinogenesis.
DNA repair genes play a key role in protecting the genome from damage caused by smoking [32].
Stem cells need to protect their genome from damage to maintain their pool and self-renewal capacity.
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