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The aggregation does not come from difficulty of dissolving a frozen structure in solid state, but the aggregates are also formed in solution starting from aggregation-free state by changing the solvent quality.
PCA, however, suffers from difficulty of interpretation of higher eigenvectors, where the information content typically decreases, the qualitative nature of information content assignment, and processing speed setbacks for truly large data sets (hundreds of thousands of observations with hundreds of thousands long arrays of variables).
Although 'brute force' DNA genotyping by dideoxy sequencing has been the method of choice for de novo SNP detection, it suffers from difficulty of DNA template amplification, limitations of PCR multiplexing per reaction, and increasing equipment costs.
The larger percentages are found in the primary tumor samples; this is consistent with the lower sequence coverage in the primary tumor samples, and the fact that tumor samples frequently contain significant admixture of normal cells resulting from difficulty of separating normal from tumor cells.
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Wright himself subsequently said the police case had suffered from difficulties of identifying people – and yet 55 prosecutions were still brought for that most serious offence.
Those errors are linked and originate from difficulties of the model to incorporate very local spatial and temporal variations of the precipitation lapse rate.
The island has been an Antarctic Specially Protected Area since 1965 (www.ats.aq/documents/recatt/Att178_e.pdf; accessed 7 October 2010) and apart from difficulties of access during the breeding season, tourism and other visits (except for purposes of specific scientific research) are not permitted.
Mann wrote that a "vocation towards educating others does not spring from inner harmony, but rather from inner uncertainties, disharmony, difficulty — from the difficulty of knowing one's own self".
Apart from the obvious difficulties of coping with such a humanitarian mess, the peacekeepers face a variety of dangers especially if the militias and soldiers refuse to back off.The first will arise from the difficulty of differentiating friend from foe.
The reason for such a small number of hospitals comes from the difficulty of obtaining data from these hospitals.
Part of the confusion arises from the difficulty of getting information from isolated communities in northeast Nigeria.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com