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Selectivity for tumor cells arises from differentials between normal and tumor cells in their effective levels of MGMT, the resistance protein responsible for the repair of DNA O-6 guanine lesions, and in their ability to repair the resultant cross-links generated from lesions that evade restoration by MGMT.
Selectivity for tumor cells arises predominately from differentials between normal and tumor cells in (1) their O-alkylguanine-DNA alkyltransferase (MGMT) content, the protein responsible for the repair of DNA O-6 guanine alkyl lesions, and (2) in their ability to repair the cross-links formed from lesions that escape MGMT repair.
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The features that differentiate embryo development in these two plant groups probably result primarily from differential gene regulation.
When he needed a break from differential equations, he would wander the aisles, pulling books at random off the shelves.
New York is one of the few major states to shy away from differential tuition pricing, which allows research universities, which are more costly to run, to charge more.
Instability during drying arises from differential shrinkage.
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Such differences can spring from differential access to phenomenological knowledge.
Note that γ is derived from differential flux.
The tools used here come primarily from differential geometry.
The results measured from differential scanning calorimetry (d.s.c).s.c
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