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Survival was measured from date of presentation rather than date of diagnosis or treatment to overcome lead-time bias.
For the 578 pandemic influenza cases, the multiple analysis of variance showed that viral loads were associated with number of days after symptom onset from date of presentation (p<0.0001) and with age (p = 0.0112).
For the 77 seasonal influenza H3 cases, the analysis of variance showed that days after onset of symptoms from date of presentation (p = 0.0223) and presence of any comorbidities (p = 0.0249) significantly affected viral loads (Table 2).
Three time intervals were calculated: time from date of first symptom to date of first presentation to provider, time from date of presentation to provider to date of diagnosis, and time from date of diagnosis to date of first treatment.
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Time from first presentation in primary care to first treatment, disease stage at diagnosis and survival time from date of first presentation in primary care were determined.
Overall survival (OS) was measured from date of initial presentation to date of death from any cause (event) or last follow-up (censoring).
The two main outcomes were stage at diagnosis (Dukes A, B, C or D) and all cause survival from date of first presentation in primary care.
The cumulative probability of Richter syndrome transformation was measured from date of initial presentation to date of the biopsy documenting Richter syndrome transformation (event), death or last follow-up (censoring).
There has been criticism that the approach commonly used to ascertain the duration of the patient interval (i.e. subtracting date of first symptom from date of first presentation) is too empirically grounded, as it assumes that there are objective, definitive dates when events occurred, which are readily collectable [ 41].
We identified those patients whose self-reported date of stroke onset from the survey differed from the date of presentation to the ED captured by the medical chart.
Twenty nine out of 94 patients (30.9%) had healed scars in < 3 weeks from the date of presentation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com