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From a methodological standpoint, the study demonstrates the importance of contextual knowledge when performing ESDA.
"It's a strong study from a methodological standpoint," said Dr. Alan Brown, an associate professor of psychiatry at Columbia who was not involved in the study.
From a methodological standpoint we bring new elements to the debate about how modularity should be measured.
The two studies are also interesting from a methodological standpoint because the results from IV and OLS estimations can be compared.
Even though this study did not aim to separate the effects of age and grade but only to estimate the effect of school entry age, it is interesting from a methodological standpoint.
So from a methodological standpoint, I think our paper makes an important contribution in two ways.
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From the methodological standpoint, almost all models include a degree of interaction between land use and transport, albeit not in the same way (the Helsinki and the South Tyrol model share the same software and are more similar; the Dortmund and the Edinburgh model are built with different relationships).
From the methodological standpoint, due to the abundance of satellite repeats in eukaryotic species, it is understandable that the literature to date mostly describes the cases of centromeric regions rich in repetitive sequences.
Reviewer number: 2 Referee 2 : Dr. Eugene Koonin, NCBI, NLM, NIH, United States of America Report form: The findings described here are of interest - in my opinion, mostly from the methodological standpoint, demonstrating the complementarity of culture-independent and targeted culturing approaches in the characterization of a microbiota.
From the methodological standpoint, the problem is naturally stated in terms of finding segments where the hybridization signal is relatively constant, delimited by breakpoints that are expected to correspond to biological features such as transcript start and stop sites or splicing sites.
From a methodological and theoretical standpoint, the respondent level SF-6D utilities are more robust than the Nichol translation.
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