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From a systems biology perspective, there is evidence that different sort of robustness emerges inherently with network complexity [35], in this paper we report evidence of temporal robustness obtained from a genome scale metabolic analysis.
Despite all these studies, little is known about miRNA regulation from a genome scale.
Despite previous advances on miRNA regulation of gene expression, little has been investigated from a genome scale.
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It is reported that approximately 33.4 % of predicted genes originated from salicoid genome-wide duplication and 15.6 % from tandem duplication on a genome scale analysis in Populus[ 30].
This study is focused on seven of the most prevalent cancer types in the world, which also have large sets of microarray gene-expression data available in the public domain, collected at a genome scale from tissues of each cancer type as well as from their corresponding noncancerous control tissues.
PTBP1 also emerged as one of the strongest hits from a genome-scale RNAi screen for regulators of Oct4 [40].
Taken together, independent evidences (i.e. phylogenetic relationship, identical exon/intron structures and conserved syntenies) strongly support that the zebrafish-specific gene pairs were raised from a genome-scale duplication event and therefore co-orthologous to their human counterparts.
ChlamyCyc results from a genome-scale metabolic pathway reconstruction to generate a pathway database for Chlamydomonas.
We decided to analyze the position of localized enzymes organizing biochemical pathways from a genome-scale metabolic network of E. coli [ 20] into Elementary Flux Patterns (EFP) [ 21].
This has been shown to be the case for the growth performance of Escherichia coli on glucose, reaching the optimal growth value calculated from a genome-scale in silico model [ 2].
From a genome-scale perspective, sRNA conservation largely mirrored that of protein-coding genes: sRNAs expressed from the chromosome ends were species-specific, while chromosome core-localized sRNAs were more highly conserved.
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