The analyses revealed which genomic regions of each strain are derived from the reference strain and which regions are highly diverged, indicating a different ancestry.
Archaeal flagella also appear to have a different ancestry, and possess many divergent characteristics (such as N-linked glycans vs. O-linked glycans, and a different mode of assembly), from bacterial flagella 51.
In this paper we report a simple technique to distinguish genomic regions of identity-by-descent (IBD) from those with different ancestry using genome resequencing results from a group of rat strains that shares a common origin but were selectively inbred for differing phenotypes.
All 11 DNAs are derived from human LCLs, which were established from individuals of different ancestry, i.e. Caucasian (C0140, C0766, C0913, and NA12760), Yoruba (NA18502, NA18858, and NA19140) and Han Chinese (NA18552).
Assuming that a causal variant at a GWAS locus is shared across ancestry groups, substantial improvements in the resolution of fine-mapping can be achieved by combining GWAS from different ancestry groups through trans-ethnic meta-analysis, by leveraging differences in the structure of LD between diverse populations [ 32, 33].
As quantities of DNA remaining from the initial STR analysis were very limited, an important pre-amble to the extended genotyping was estimation of likely success in assigning ancestry, i.e. choosing the approach that gave the minimum misclassification error from amongst the different ancestry marker sets available.
They also showed that a few individuals from the Scottish population have a variable pattern of genes from different ancestries, with part of this group of individuals having more than a 4%% of non-European origin according to the rare allele analysis.
Meta-analysis of samples from many different ancestries can be challenging when attempting to discover associations, but ancestral differences in LD can be advantageous when attempting to fine-map.
