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In the early 1960s, John Gurdon transplanted nuclei of adult frog intestinal cells into unfertilized eggs and generated tadpoles [4,5].
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The embryonic tissue came, initially, from intestinal cells, and the method was eagerly adopted in the rush to develop vaccines against polio.
In 1958 British biologist John Bertrand Gurdon successfully carried out nuclear transfer using DNA from adult intestinal cells of African clawed frogs (Xenopus laevis).
Pockets of intestinal cells, for example, can only hold a few cell generations.
Now, using X-ray crystallography, researchers from the University of British Columbia have shown what happens at a molecular level when the bacteria bind to intestinal cells.
When a pathogen infects our guts, it almost always begins by latching onto glycans sugar molecules on the surfaces of our intestinal cells.
When the Nod2 gene is damaged, researchers said, the immune system probably overreacts and mistakenly attacks healthy intestinal cells, causing chronic inflammation.
The researchers introduced "normal," enzyme-producing salmonella bacteria and mutant bacteria that lack the enzyme into intestinal cells and videotaped the results.
Part of the toxin then enters the intestinal cells.
No toxicity against Caco-2 intestinal cells was observed.
A triple co-culture model of intestinal cells was utilized to more closely mimic the intestinal epithelium.
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CEO of Professional Science Editing for Scientists @ prosciediting.com