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Colistin pharmacokinetics are expected to be dramatically altered in critically ill patients, because they are frequently prone to large swings in distribution volume, fluctuations in renal clearance, and variable protein binding.
Of note, despite similar severity of hypoxemia and impairment of respiratory mechanics, IPAF patients had a significantly higher ICU-LOS and duration of IMV and required more frequently prone positioning and ECMO.
Are certain genomic regions or certain genes more frequently prone to de novo mutations?
The prostate retains the potential for cell proliferation, differentiation, and morphogenesis, and it is frequently prone to benign and malignant tumor formation (1, 2).
The jawbone, despite its uniquely discrete location and function, remains part of the skeletal system and is metabolically regulated along with other aspects of the skeleton, including the vertebrae and long bones sites frequently prone to osteoporotic fracture.
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Kongo's system of manikongo succession was often prone to disputes, frequently between sons or between sons and brothers of former kings, and at times the rivals would form factions, some of which were long-lived.
CNV genotyping is often prone to error and cross-validation with independent methods is frequently required.
Court documents stated that his mother told agents that her son was "frequently depressed, prone to verbal outbursts and may be suicidal".
Opposition activists have frequently been prone to exaggeration, claiming wrongly for example that they were being fired on by helicopters.
In person, Weinberger is genial and self-contained; he smiles frequently and is prone to wisecracks.
Koch was outspoken, intolerant of opposition, frequently capricious, and prone to see himself as above politics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com