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The horrors of the Sierra Leone war have frequently perturbed the solemn setting of The Hague courtroom, with its officers in black robes with neatly starched bevvies and its crimson-robed judges high on the dais.
In this chapter, we review the current state of knowledge of endometrial cancer genomics, both in the context of histopathological subtypes and their underlying molecular subgroups, with an emphasis on the genes and pathways that are frequently perturbed.
The observation that these genes are frequently perturbed in other cancers further argues for the relevancy of the AI genes.
If tumors frequently target biological modules that execute key biological processes, and network knowledge about such modules is available, we hypothesized that it would be possible to algorithmically identify frequently perturbed modules, and from these modules identify candidate driver mutations.
Genetic events in these mouse models can mimic those that are frequently perturbed in human tumors.
This regulation sets the level of cellular motility and is frequently perturbed in cancer cells of breast and lung origins.
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Ezard et al. [9] noted that anthropogenic impacts frequently perturb populations away from their expected stable stage distributions (SSD), with the result that transient dynamics following a disturbance can depart significantly from the dynamics associated with asymptotic conditions.
Mutant sarcomeric proteins frequently perturb sarcomere assembly.
On the other hand, somatic mutations and CNVs in cancer genomes frequently perturb the expression level of affected genes and thus disrupt pathways controlling normal growth.
On the other hand, CNA and changes in methylation status frequently perturb the expression levels of the altered genes or other genes under their control.
Pathway analyses for genes that were significantly different between the two groups were undertaken with the use of GenMapp software, and identified pathways that are frequently reported to be perturbed during carcinogenesis (Tables 2a and 3a).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com