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However, challenges with recruitment in RCTs are known to be common and complex in health care, and frequently more difficult than anticipated [ 1- 4].
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Historically, however, determining a response has frequently been more difficult than determining tumor progression (treatment failure).
One: Randomized trials are more difficult than they look, and "experiments are frequently subject to practical problems that undermine any claims to statistical or epistemic superiority".
It's a pretty good practice to find a second source for its claims – though that is more difficult than it seems, since the second source has frequently lifted its information unchecked from Wikipedia.
Measuring blood loss is more difficult than visual estimation, and thus has been implemented less frequently.
Patients find it more difficult than expected to accomplish partner notification on their own[ 71], but frequently want assistance [ 72].
It is much more difficult than poetry.
This is more difficult than it sounds.
Are some comparisons more difficult than others?
More difficult than evil ones?
That is far more difficult than composing.
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CEO of Professional Science Editing for Scientists @ prosciediting.com