Sentence examples for frequent variants with from inspiring English sources

As an example, a larger discovery sample is necessary if the genetic architecture consists of many low frequent variants with small effect sizes, as opposed to a genetic architecture that has fewer frequent variants with relatively high effect sizes.

The role of less frequent variants with a strong effect size in complex diseases is now recognized [ 23, 24].

According to their minor allele frequencies (MAFs) in the patients they can be divided into two groups: rare variants with MAFs between 0.0025 and 0.005, and frequent variants with MAFs > 0.005.

It is highly likely that both rare and common alleles will contribute to complex phenotypes and so effect sizes may be expected to differ quite widely, with rare variants with large effects complemented by a large number of frequent variants with small effects.

However, if in using these tools, we focus exclusively on single infrequent variants under the assumption that they will invariably exert their effects in splendid isolation, then there is a very real danger that we shall inadvertently exclude from consideration those more frequent variants with modest effects, blithely ignoring their potential for interaction with the rare variants.

To elucidate the functional effect of the ABCA4 variant c.5461-10T→C, ofe of the most frequent variants associated with Stargardt disease (STGD1).

Furthermore, since peptides were not recognized based on their frequency in the population, it remains unclear by which mechanisms variability-inclusive antigens (i.e., constructs enriched with frequent variants) expand CTL recognition.

Markers with frequent variants captured greater than 30% of the phenotypic variation in this population in both datasets.

However, the present observations of decreased pain sensitivity in carriers of a TRPA1 haplotype, of which rs1198795 is a part, point at a decreased function of TRPA1 nocisensors associated with the frequent variants analyzed here.

We find that only a small fraction of phenotypic variation can be attributed to SNPs with low frequent variants.

Our sample size therefore is appropriate for the purpose of the analysis, and large enough to allow stratified and interaction analyses, especially to find even small interaction effects with the most frequent variants, and larger interaction effects for less common variants.