Sentence examples for frequent somatic mutations from inspiring English sources

The most frequent somatic mutations and Ig gene joints were then introduced into an engineered single-chain Fv (scFv) that expressed the germline-encoded VH and VL amino acid sequences.

A recent study has reported frequent somatic mutations in the heterotrimeric G protein α-subunit (GNAQ) in a subset of melanocytic neoplasms which do not present alterations in the RAS or BRAF genes [3].

Frequent somatic mutations have recently been identified in the ras-like domain of the heterotrimeric G protein α-subunit (GNAQ) in blue naevi 83%, malignant blue naevi (50%) and ocular melanoma of the uvea (46%).

The suppressor pathway, observed in >80% of CRC cases, involves abnormalities of the APC/wingless signalling pathway and is characterized by frequent somatic mutations of oncogenes and loss of heterozygosity of tumor suppressor genes, chromosomal instability, and microsatellite stable (MSS) tumors.

Frequent somatic mutations in NF1 have been previously shown to co-occur with TP53 mutations [ 17].

Less frequent somatic mutations have been described in AXIN1, phosphoinositol 3-kinase A (PI3KA), and K-Ras.

Next, evaluation of somatic sets related to cancer prognosis and treatment response prediction, and to genetic and genomic alterations (see Materials and Methods), revealed significant asymmetrical distribution of "driver kinases" [34], [35]; that is, kinases whose deregulation through frequent somatic mutation contributes to tumor development and/or progression ("driver mutations").

In our patient cohort, we found significantly more frequent somatic KRAS mutations in cervical adenocarcinoma, whereas PIK3CA mutations were more frequently found in squamous cell carcinoma (manuscript submitted).

Partition in the two major groups (G1 G3/G4 G6) showed that G1 G3 subgroups included 57% of HBV-HCC and were enriched in large tumours (>55 mm; p=0.006; figure 5), characterised by frequent HBX gene inactivating mutations (p=0.001; figure 5) and frequent somatic AXIN1 mutations (p=0.03; figure 5).

Several independent reports proposed that KLF6 is a tumor suppressor gene product due to downregulation of KLF6 expression or frequent somatic inactivating mutations were found within the klf6 gene in prostate carcinoma, colorectal tumors, glioblastoma, hepatocellular carcinoma and lung-derived tumors [8], [9], [10], [11], [12], [13], [14], [15].

A previous analysis of FLCN-related RCCs revealed frequent somatic frameshift mutations or LOH.