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Frequent samples were obtained for measurement of plasma glucose and insulin concentrations.
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Data from patients with frequent sampling were analyzed non-compartmentally, whereas data from both patients with frequent and patients with sparse sampling were used for population pharmacokinetic analysis.
On days 9 and 10, more frequent sampling was conducted during the aerobic and anaerobic phases.
Frequent sampling is needed to obtain robust and precise parameter estimates.
Frequent sampling is therefore an advantage in the evaluation of endotoxemia compared with analysis at only one point in time.
Lower pollutant concentrations have been observed in the warm season due to better ventilation conditions and therefore less frequent sampling was performed.
Because more frequent sampling is very difficult in postoperative patients, the time points were carefully chosen based on tumor cell biology.
Because ApEn may be applied to short, noisy data sets, it was applied to assess the variation of parameters in which frequent sampling is more difficult (e.g. a blood test is necessary) and a paucity of data exists.
Further, frequent sampling was essential for the initial part of the study due to the lack of the literature data regarding the permeation of a dye loaded into nanoparticles through MN-treated skin.
On day 12, each gelding received an intravenous injection of 30 μg gonadotropin-releasing hormone (GnRH) analog and 3 mg thyrotropin-releasing hormone (TRH); frequent blood samples were drawn to characterize the luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin responses.
Frequent blood samples were drawn for 12 hours after dose.
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