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In the first place, when large-scale mutations are made less frequent relative to point mutations, the genome expansion is less pronounced and the success rate is lower.
If mutants with δ = 0 are only considered, negative epistasis is rather frequent relative to additive neutral case: As much as 35% of the mutants are deleterious at d = 5 even if they carry only neutral substitutions.
As in yeast, we observed that nonframeshifting indels in disordered regions are much more frequent relative to Pfam domains and other ordered regions, and show a similar rate to indels in pseudogenes (and pseudogene introns) that are multiples of three.
If these rearrangements are frequent relative to other (ecological or geographical) processes influencing speciation rates, the cytogenetic parameters could drive speciation and possibly be responsible for the great species richness in Cicindela.
The incidence rate of recurrent events in cohort B was almost half that of cohort A. Likely explanations of this difference are that among cohort B patients, there were more women, age was somewhat younger, familial CVD was less prevalent, and prior myocardial infarction was less frequent relative to prior stroke.
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By contrast, expectation-based accounts such as surprisal predict that the less frequent object relative should be harder to process.
Inset (i) to Figure 5a shows the seasonal distribution as the number of days each month likely to experience these damaging events while inset (ii) suggests that they are most frequent at relative humidity values around 90%. Thus it is days with these rare, but very high humidity values that are likely to impose the most critical stress on wood.
"In 2013, Hispanics continued the trend of oversampling as frequent moviegoers relative to their proportion of the population and the total number of frequent Hispanic moviegoers (11.6 million) continues to grow," the report reads.
The most frequent ADRs relative to usage were calculated by using data of all drugs administered to one tenth of patients admitted.
Factors independently associated with more frequent (n=4+) relative to less frequent (n=3) admissions included having congestive heart failure (p=0.003), higher social isolation scores (p=0.040) and higher Charlson Comorbidity Index scores (p=0.049).
That the group of operational genes comprises multiple underlying histories does not make this grouping meaningless: the evolutionary resemblance between operational genes (i.e., their more frequent transfer relative to other genes), if correct, deserves recognition (Leigh et al. 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com