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Patients with ovarian cancer have a low 5-year survival with frequent recurrences and rapid metastases to the peritoneal cavity with concomitant malignant pleural effusions.
Bladder cancer is a common malignancy requiring a high degree of surveillance because of the frequent recurrences and the poor clinical outcome of invasive disease.
These carcinomas typically show frequent recurrences and late distant metastases [ 11].
Generally, the history of AF is long, burdened by frequent recurrences, and associated with symptoms (in two thirds of patients).
The disease is characterized by frequent recurrences and poor clinical outcome when tumors progress to invasive disease.
Findings associated with more frequent recurrences and metastases include lobulated/irregular contours, oval shape, mediastinal fat or great vessel invasion and pleural seeding (Fig. 1a).
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Although the majority of tumors initially respond to standard treatments combining surgery and chemotherapy with platinum based chemotherapy, frequent recurrence and subsequent acquired chemoresistance are responsible for the therapeutic failure, leading to an overall 5 years survival rate of 30%.
Poor prognosis may be due to the frequent recurrence and distant metastasis at an early stage, despite radical surgeries performed.
Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival.
Triple-negative breast cancer are difficult to treat, as they do not respond to hormone and Herceptin therapies and are especially aggressive due to their frequent recurrence and high metastatic potential (Dent et al, 2007; Hurvitz and Finn, 2009).
Currently, lower ANXA2 expression in prostate cancer patients, compared to that in benign prostatic hyperplasia, correlates with an advanced clinical stage, more frequent recurrence, and regional lymph node and distant metastasis and may serve as a useful biomarker [ 73].
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