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The basis of the treatment is 20 30 dosages of asparaginase during intensification and frequent pulses of vincristine and steroid during maintenance.
While we did not observe a substantial difference between LOVpep (t1/2 ∼ 30 s) or V416I LOVpep (t1/2 ∼ 370 s) when frequent pulses of light (every 12 s) were applied, with less frequent light pulses we observed a reduction in light-dependent reporter activation with wild-type compared with V416I (Supporting Information Figure S2a).
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The latest trend is to take fast, frequent pulses on employee engagement.
A faster response would allow the cellular system to accurately decode and transduce inputs consisting of frequent pulses.
In other such CAIS or PAIS mutations, transcriptional activity normalized either after administration of supraphysiologic concentrations of endogenous androgens (e.g., testosterone or dihydrotestosterone, DHT), synthetic androgens (Mibolerone or R1881), or after treatment with frequent pulses (up to every four hours) of physiologic doses of DHT [11] [13].
So it can keep one eye on the sky while another watches a suspicious drone with more frequent pulses.
After 66 h of frequent pulsing, desensitization had occurred and serum LH concentrations were similar to pretreatment concentrations, but serum FSH had decreased to 53% of pretreatment levels (p < or = 0.0008).
The signals must therefore be strengthened at frequent intervals by converting pulses of light into electric pulses, then amplifying the electric pulses electronically and reconverting them into light pulses to be sent on their way to the next amplifying station.
Throughout the season, a shift in the Hadley Circulation towards the Tasman Sea resulted in more frequent episodes of strong wind shear and regular pulses of dry air into the deep tropics, significantly hindering tropical cyclogenesis.
But previous tactile sensors have been analogue devices, where more pressure produces a stronger electrical signal, rather than a more frequent stream of pulses.
Frequent automated sampling of plasma corticosterone levels has demonstrated that HPA activity comprises a pulsatile (ultradian) pattern, with pulses of secretory activity occurring approximately once every 60 90 min, the changing amplitude of which determines the circadian rhythm (eg, 11, 12).
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