Sentence examples for frequent mutations the from inspiring English sources

For the well- known driver genes EGFR, CDKN2A, KRAS, STK11, TP53 which already have computed P-values of zero due to frequent mutations, the effect of scoring makes little difference.

In the regime of frequent mutation, the evolutionary dynamics is different from the rare mutation regime considered here in that there is a trend towards increased mutational robustness for increasing Mμ [ 33- 35].

The frequent mutations of the synonymous codons usually happen in the third position, whereas some mutations occurring in the first or the second positions are non-synonymous.

CFTR DNA test: screening test to search for the most frequent mutations in the population from which the patient originates.

The high prevalence of BC and the presence of frequent mutations of the BRCA1 gene emphasize the need for improving screening programs and individual testing/counseling.

Our findings reveal a novel evolutionary mechanism for regulation of chromatin compaction and may explain the frequent mutations of the H2A N-terminus in cancer.

The most frequent mutations in the luminal A subtype are PIK3CA (45%), MAP3K1 and GATA3 (13% each), TP53 (12%), and CDH1 (9%).

The initial testing should check for 35delG and/or the other most frequent mutations in the background population.

The next most frequent mutations in the N1 subtype were I222V, H274Y and N294S (Table 3).

Xu, G. et al. Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome.

SHM results in the generation of very frequent mutations in the IGHV genes.