Sentence examples for frequent mutations that from inspiring English sources

Over the years, he and his team have defined the mechanisms of the most frequent mutations that lead normal immune cells to transform into lymphoma.

The 3' end of the E2 gene (hypervariable region 1: HVR1) shows frequent mutations that have the nature of a quasispecies (QS), defined as a population of closely related but different viral genetic sequences co-existing in the host and evolving as a single unit [1].

Both mutants showed a bias to G/C-to-A/T transitions, which were the most frequent mutations that occurred (45.0% in AS and 34.9% in AM).

A late mutation was found in PIK3C2B which interacts with PIK3CA, one of the most frequent mutations that has been reported in breast cancer [ 43, 57].

We were also able to detect other less frequent mutations that are likely to perturb the same pathways and these may cause resistance to EGFR-targeted therapies, as reported for KRAS, PIK3CA and BRAF.

To understand the functional features of this novel S59P mutation, we set out to compare it with two frequent mutations that are well known in the literature: the R92Q and T50M mutations [ 20- 231 31- 33, 38, 44, 45].

However, surprisingly, genetically engineered mouse ES cells expressing BRCA1 with a substitution of alanine for isoleucine at position 26 (I26a), a frequent mutation that disrupts the binding to the E2 subunit without perturbing BARD1 binding [ 90], do not exhibit HR failure [ 95].

Our study failed to identify frequent FH mutations that would be consistent with the common nature of nonsyndromic UL but cannot exclude FH as a candidate target regulated by the associated lncRNA.

As initial data have shown that a 5' poly(A) HT in inlA, which encodes the L. monocytogenes internalin A protein, shows frequent frameshift mutations that result in a truncated and inactive 8 aa peptide [ 7, 10], we used this gene as a model to further probe the contributions of HTs to phase-shifting and reversible gene inactivation in bacterial pathogens.

The frequent genomic mutation that leads to HBeAg negativity is the mutation of the nucleotide (nt) 1896 from G to A (G-A).

Imatinib-resistant advanced GIST continues to pose a therapeutic challenge, likely due to the frequent presence of multiple mutations that confer drug resistance.