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We identified frequent mutations of epigenetic modifiers, most notably mutations of DNMT3A, in 33% of adult MPAL patients.
Recent sequencing efforts have identified several novel frequent mutations of histone modifying and chromatin remodeling genes in ccRCC including PBRM1, SETD2, BAP1, and KDM5C.
Frequent mutations of surface molecules, hemagglutinin (HA) and neuraminidase (NA), contribute to low efficacy of the annual flu vaccine and therapeutic resistance to standard antiviral agents.
The basal-like cell lines were ER-negative and exhibited more frequent mutations of TP53 and PTEN, consistent with findings in basal-like tumors [3], [77].
The frequent mutations of influenza genes, particularly those encoding surface hemagglutinin (HA) and neuraminidase (NA) proteins, allow the virus to evade the host immune system.
Many studies have reported frequent mutations of splicing factors in MDS and AML.
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Influenza viruses have periodically caused pandemic due to frequent mutation of viral proteins.
An application for a frequent mutation of p53 tumor suppressor is presented, illustrating the complementarity of druggability prediction approaches, the remaining challenges and potential new drug development perspectives.
The robustness is crucial for the potent inhibitor design by considering the frequent mutation of the virus.
ΔF508 is the most frequent mutation of CFTR that causes misfolding of a partially functional protein.
Thus, we compared these mutations (delTyr) with the most frequent mutation of KIT exon 11 in GISTs (delWK557 558).
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