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The most frequent mutations in each dataset were relatively common, validating our approach.
Even with the 10,000 most frequent mutations in TCGA, only 68% of Broad patients are covered.
b The ten most frequent mutations in TCGA are presented with their coverage of TCGA and Broad patients.
Three of the top 10 most frequent mutations in TCGA are not seen at all in the Broad dataset.
However, frequent mutations in this gene allow the virus to evade host immune responses and conventional prophylaxis and treatment.
Interestingly, there is a marked difference in the prevalence of the 10 most frequent mutations in TCGA between the two datasets (Fig. 4b).
A panel of 400 hotspots delineated in the TCGA dataset is highlighted for ease of interpretation the 400 most frequent mutations in TCGA cover 55.49% of Broad patients.
Thirty 18- to 24-mer oligonucleotide probes were designed to target the most frequent mutations in three polymorphic loci of Sinorhizobium meliloti and S. medicae.
Chromatin alterations are integral to the pathogenic process of cancer, as demonstrated by recent discoveries of frequent mutations in chromatin-modifier genes and aberrant DNA methylation states in different cancer types.
The next most frequent mutations in the N1 subtype were I222V, H274Y and N294S (Table 3).
Several other reported, but less frequent, mutations in this region that block diphthamide synthesis include Gly719Arg, Ile714Asn, and Ser584Gly.
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