Sentence examples for frequent mutations and from inspiring English sources
These studies confirmed that the most commonly mutated gene was AR, however no single gene other than AR had frequent mutations and even common, broadly mutated oncogenes such as PIK3CA, KRAS, and BRAF are not commonly mutated in prostate cancer [ 9].
Misalignment of a nascent strand and the use of an alternative template during DNA replication, a process termed "template-switching", can give rise to frequent mutations and genetic rearrangements.
These regions have less frequent mutations and possible substitutions are either positive in nature or have similar IM contact architecture.
We produced in vitro 15 possible proteins resulting from the combination of the four most frequent mutations and we tested their catalytic activity and enzymatic stability.
Crohn's disease emerges as a complex, multigenic disease that is identified with both frequent mutations and rare mutations, rather than high penetrance mutations in gene analysis [ 19].
We then specifically examined correlations between our lncRNAs and expression of EZH2, a transcriptional repressor, implicated in tumorgenesis in DLBCL due to frequent mutations and with known interactions with lncRNAs [ 22, 23].
The OC-related mutation I117V was the most frequent mutation, and it accounted for 63% of all mutants.
This study also identifies RB1CC1 as a novel target of frequent mutation and aberrant upregulation in MSI-H colorectal tumors.
This screening identified frequent mutation and aberrant mRNA upregulation of RB1CC1 in MSI-H colorectal tumors, which deserves further investigation of its potential involvement in colorectal tumorigenesis.
I314V was the most frequent mutation, and if its frequency is compared to frequency of avian N2, where the same mutation was also prevalent (Table 3), then this NA variant might have originated from avian NA, where it was likely a part of a normal gene pool variation for the N2 subtype.
Urobasal A (UroA) tumors show papillary growth, good prognosis and frequent mutation and expression of FGFR3.
