Several specific residues for frequent mutations were found and the mutational frequency of reductase domains was much higher than that of heme domains.
The most frequent mutations in each dataset were relatively common, validating our approach.
The most frequent mutations affect TERT promoter (60%), associated with an increased telomerase expression.
Even with the 10,000 most frequent mutations in TCGA, only 68% of Broad patients are covered.
b The ten most frequent mutations in TCGA are presented with their coverage of TCGA and Broad patients.
Three of the top 10 most frequent mutations in TCGA are not seen at all in the Broad dataset.
We identified frequent mutations of epigenetic modifiers, most notably mutations of DNMT3A, in 33% of adult MPAL patients.
However, frequent mutations in this gene allow the virus to evade host immune responses and conventional prophylaxis and treatment.
Interestingly, there is a marked difference in the prevalence of the 10 most frequent mutations in TCGA between the two datasets (Fig. 4b).
Influenza viral strains with highly efficient polymerases can evade the IFN response in vivo due to their frequent mutations occurred during replication (Grimm et al., 2007).
Secondly, frequent mutations make it difficult to deal with HA mutants because time-consuming methods are required for each mutant preparation.
