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It is obvious that life-cycle management of medical devices has shortened due to frequent modifications in response to requests from the clinical field (Act on Securing Quality, Efficacy and Safety of Pharmaceuticals, Medical Devices, Regenerative and Cellular Therapy Products, Gene Therapy Products, and Cosmetic; Levesque et al., 2014).
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Phosphorylation of p53 at Ser has been shown to be a frequent modification in tumours (Minamoto et al, 2001).
As experience with this regimen has accrued, and as we have learned how to manage the toxicities, we have been presented with a new set of questions: the effect of frequent modifications; optimal use in all stages of pancreatic cancer; integration with both established and emerging therapies; how to evaluate response; and the incorporation of evolving molecular data.
"As the text of the Constitution makes plain, it is Congress that has been assigned the task of defining the scope of the limited monopoly that should be granted to authors or to inventors in order to give the appropriate public access to their work product;" that "task involves a difficult balance between [competing interests]" as reflected in the frequent modifications of the relevant statutes.
Recent tighter legislation and control over issues like sustainability and disability discrimination have resulted in the need for more frequent modifications to building regulations.
Basic unity prevailed despite numerous battles behind the scenes and frequent modifications to the sanctions.
Bowen's Deputy Inspector General, Glenn Furbish, said separately in the interview that the cost of many contracts was steadily increased due to frequent modifications.
However, some committee members raised concerns about incompatibilities between implementations and frequent modifications of the standard.
Codification helps to clarify EU legislation that has undergone frequent modifications.
To allow the user to easily make such judgments and to reduce chances for creating inconsistencies due to frequent specification modifications, in this paper we describe an intuitive, formal, and expressive specification method that integrates top-down decompositional and scenario-based compositional methods.
(65) Binary Cr-DNA adducts are the most frequent DNA modifications in the in vitro reductions of Cr VI).
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