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Most frequent medications used were midazolam (92.6%), propofol (85.3%) and temazepam (75.1%).
Less frequent medications were grouped together by substance class and type of combination to allow for reasonable statistical analysis (cohort size).
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In contrast, none of those (2.3 %) who recorded they used medication very frequently in their diary reported very frequent medication in their interview.
b model 2: fully adjusted with frequent medication intake.
Frequent medication use also represents an avoidance strategy on a behavioural level.
Our most frequent medication-based AEs were related to incorrect prescriptions.
Of the 346 participants who reported headaches in their interview, only three (0.9 %) also reported very frequent medication use, whereas none of these participants documented very frequent medication use in their diary.
Epidemiological studies do not unambiguously show whether frequent medication intake is the cause or consequence of chronic headache.
There was no agreement between information obtained in interviews and in diary recordings for very frequent medication use (Kappa −0.01, 95 % CI: −0.22 0.00).
The prevalence of chronic migraine (CM) in the general population is around 2%. CM occurs with impaired quality-of-life and frequent medication overuse.
In addition, this study analyzed the sensitivity, specificity, and positive and negative predictive values of agreement between retrospectively-reported headaches experienced at least every other day, frequent medication, and prospective information recorded in headache diaries.
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