The second (and more frequent) mechanism results from a scission of the primary macroradical, a mechanism which could be stress-activated.
Recruitment of the protein lysine methyltransferase DOT1L at aberrant loci is a frequent mechanism driving acute lymphoid and myeloid leukemias, particularly in infants, and pharmacological inhibition of DOT1L extends survival in a mouse model of mixed lineage leukemia.
The most frequent mechanism of injury was precipitation (23.3 %).
Falls from beds (n = 177) were the most frequent mechanism of injury.
The most frequent mechanism of injury was a fall on the shoulder or elbow while jumping during a game.
Fall from a height has been described as the most frequent mechanism of self-inflicted trauma [2].
On admission, the most frequent cause of TBI was motor vehicle accident (142 patients, 54.8%) and the most frequent mechanism was head striking an object (170 patients, 65.6%).
Whilst the second most frequent mechanism, transport related fatalities accounted for the majority of traumatic deaths in the remote and very remote regions of the Top End, and were twice as likely in the remote compared with the accessible regions.
Contact with a ball was a frequent mechanism of injury in soccer; however, we are unable to state what proportion were attempts to head the ball and what proportion were completely unintentional ball contacts to the head.
Head striking an object (68.4% in mTIH group and 63.2% in non-mTIH group) was the most frequent mechanism of TBI, followed by head being struck (19.3% in mTIH group and 21.1% in non-mTIH group) and whiplash (12.3% in mTIH group and 15.8% in non-mTIH group) (p = 0.705).
Although studies have linked repetitive heading to measurable brain impairment among players (Matser et al. 1998; Matser et al. 1999; Stewart et al. 2017, Virgilio et al. 2016), according to recently published literature, the most frequent mechanism associated with acute head injuries among soccer players is player-to-player contact (Andersen 2004; Comstock et al. 2015; Maher et al. 2014).
