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The most frequent locus in the control group was 9p.
We have previously reported that recurrent homozygous deletions appear to specifically target MAP2K4 in primary ovarian tumors, and the gene lay in a minimal region of loss of heterozygosity (LOH) in 68% (72/106) of the cases, the second most frequent locus targeted by LOH [ 18].
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The most frequent loci of manifestation are the lungs.
In the cases, the most frequent loci were 9p, 17p, and 5q.
Moinfar and colleagues [ 60] demonstrated that 77% of columnar cell lesions (either with or without atypia) harbour chromosomal abnormalities at least in one locus and the most frequent loci of LOH were 11q21-23.2, 16q23.1-24.2, and 3p14.2 [ 60].
Although power for larger numbers of loci was lower, it was still about 96% with 100 equi-frequent loci.
ENGAGE was estimated to have a power of 99.26% to detect a McManus model with 30 equi-frequent loci, and 98.96% with 40 loci.
These results suggest that the divergence between the two detected MHC class II loci is either hindered by frequent inter-locus recombination or by the fact that both loci evolve under the same selective forces.
The frequent AXIN1 locus LOH in our study could point to a gene dosage effect independent of Wnt pathway activation.
Using a threshold T/N ratio >1.0, 19 loci that reached statistical significance were considered frequent LOH loci.
The micro-deleted region was defined when 3 or more adjacent SNP markers were considered frequent LOH loci.
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